Publikationen seit 2000

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  • Weidinger D, Jacobsen J, Alisch D, Uebner H, Heinen N, Greune L, Westhoven S, Jamal Jameel K, Kronsbein J, Pfaender S, Taube C, Reuter S, Peters M, Hatt H, Knobloch J
    Olfactory receptors impact pathophysiological processes of lung diseases in bronchial epithelial cells
    Eur J Cell Biol. 2024 Jun;103(2):151408. doi: 10.1016/j.ejcb.2024.151408. EpubPubMed

  • Kim JM, Dziobaka S, Yoon YE, Lee HL, Jeong JH, Lee IR, Weidinger D, Yang C, Kim D, Gulperi Y, Lee CK, Sohn J, Song G, Hatt H, Lee SJ
    OR2H2 Activates CAMKKβ-AMPK-Autophagy Signaling Axis and Suppresses Senescence in VK2/E6E7 Cells
    Pharmaceuticals (Basel). 2023 Aug 29;16(9):1221. doi: 10.3390/ph16091221.PubMed

  • Weidinger D, Jamal Jameel K, Alisch D, Jacobsen J, Bürger P, Ruhe M, Yusuf F, Rohde S, Störtkuhl K, Kaufmann P, Kronsbein J, Peters M, Hatt H, Giannakis N, Knobloch J
    OR2AT4 and OR1A2 counterregulate molecular pathophysiological processes of steroid-resistant inflammatory lung diseases in human alveolar macrophages
    Mol Med. 2022 Dec 12;28(1):150. doi: 10.1186/s10020-022-00572-8 PubMed

  • Herbrechter R, Beltrán LR, Ziemba PM, Titt S, Lashuk K, Gottemeyer A, Levermann J, Hoffmann KM, Beltrán M, Hatt H, Störtkuhl KF, Werner M, Gisselmann G.
    Effect of 158 herbal remedies on human TRPV1 and the two-pore domain potassium channels KCNK2, 3 and 9
    J Tradit Complement Med. 2020 Apr 27;10(5):446-453. doi: 10.1016/j.jtcme.2020.04.005. eCollection 2020 Sep.PubMed

  • Lieder B, Hoi J, Burian N, Hans J, Holik AK, Beltran Marquez LR, Ley JP, Hatt H, Somoza V.
    Correction to Structure-Dependent Effects of Cinnamaldehyde Derivatives on TRPA1-Induced Serotonin Release in Human Intestinal Cell Models
    J Agric Food Chem. 2020 Apr 29;68(17):5018. doi: 10.1021/acs.jafc.0c02180. Epub 2020 Apr 16.PubMed

  • Lieder B, Hoi J, Burian N, Hans J, Holik AK, Beltran Marquez LR, Ley JP, Hatt H, Somoza V.
    Structure-Dependent Effects of Cinnamaldehyde Derivatives on TRPA1-Induced Serotonin Release in Human Intestinal Cell Models
    J Agric Food Chem. 2020 Apr 1;68(13):3924-3932. doi: 10.1021/acs.jafc.9b08163. Epub 2020 Mar 23.PubMed

  • Pützer A, Brüne M, Hatt H, Wolf OT.
    Hedione Reduces Subjective Vicarious Stress
    Front Behav Neurosci. 2020 Jan 17;13:297. doi: 10.3389/fnbeh.2019.00297. eCollection 2019.PubMed

  • Lee SJ, Depoortere I, Hatt H
    Therapeutic potential of ectopic olfactory and taste receptors.
    Nat Rev Drug Discov. 2018 Nov 30. pii: 10.1038/s41573-018-0002-3. doi: 10.1038/s41573-018-0002-3.PubMed PDF

  • Gisselmann G, Alisch D, Welbers-Joop B, Hatt H
    Effects of Quinine, Quinidine and Chloroquine on Human Muscle Nicotinic Acetylcholine Receptors.
    Front Pharmacol. 2018 Nov 20;9:1339. doi: 10.3389/fphar.2018.01339. eCollection 2018.PubMed

  • Cheret J, Bertolini M, Ponce L, Lehmann J, Tsai T, Alam M, Hatt H, Paus R
    Olfactory receptor OR2AT4 regulates human hair growth.
    Nat Commun. 2018 Sep 18;9(1):3624. doi: 10.1038/s41467-018-05973-0.PubMed

  • Wojcik S, Weidinger D, Stander S, Luger T, Hatt H, Jovancevic N
    Functional characterization of the extranasal OR2A4/7 expressed in human melanocytes.
    Exp Dermatol. 2018 Aug 9. doi: 10.1111/exd.13764.PubMed

  • Massberg D, Hatt H
    Human Olfactory Receptors: Novel Cellular Functions Outside of the Nose.
    Physiol Rev. 2018 Jul 1;98(3):1739-1763. doi: 10.1152/physrev.00013.2017.PubMed Journal Homepage

  • Weber L, Schulz WA, Philippou S, Eckardt J, Ubrig B, Hoffmann MJ, Tannapfel A, Kalbe B, Gisselmann G, Hatt H
    Characterization of the Olfactory Receptor OR10H1 in Human Urinary Bladder Cancer.
    Front Physiol. 2018 May 16;9:456. doi: 10.3389/fphys.2018.00456. eCollection 2018.PubMed

  • Kalbe B, Osterloh M, Schulz VM, Altmuller J, Becker C, Osterloh S, Hatt H
    OR2H2 regulates the differentiation of human myoblast cells by its ligand aldehyde 13-13.
    Arch Biochem Biophys. 2018 May 1;645:72-80. doi: 10.1016/j.abb.2018.03.017. Epub 2018 Mar 17.PubMed

  • Weber L, Massberg D, Becker C, Altmuller J, Ubrig B, Bonatz G, Wolk G, Philippou S, Tannapfel A, Hatt H, Gisselmann G
    Olfactory Receptors as Biomarkers in Human Breast Carcinoma Tissues.
    Front Oncol. 2018 Feb 15;8:33. doi: 10.3389/fonc.2018.00033. eCollection 2018.PubMed

  • Jovancevic N, Khalfaoui S, Weinrich M, Weidinger D, Simon A, Kalbe B, Kernt M, Kampik A, Gisselmann G, Gelis L, Hatt H
    Odorant Receptor 51E2 Agonist beta-ionone Regulates RPE Cell Migration and Proliferation.
    Front Physiol. 2017 Nov 30;8:888. doi: 10.3389/fphys.2017.00888. eCollection 2017.PubMed

  • Wolf S, Jovancevic N, Gelis L, Pietsch S, Hatt H, Gerwert K
    Dynamical Binding Modes Determine Agonistic and Antagonistic Ligand Effects in the Prostate-Specific G-Protein Coupled Receptor (PSGR).
    Sci Rep. 2017 Nov 22;7(1):16007. doi: 10.1038/s41598-017-16001-4.PubMed

  • Kurtenbach S, Giessl A, Stromberg S, Kremers J, Atorf J, Rasche S, Neuhaus EM, Herve D, Brandstatter JH, Asan E, Hatt H, Kilimann MW
    The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia.
    Sci Rep. 2017 Aug 16;7(1):8409. doi: 10.1038/s41598-017-08543-4.PubMed

  • Wolf S, Gelis L, Dorrich S, Hatt H, Kraft P
    Evidence for a shape-based recognition of odorants in vivo in the human nose from an analysis of the molecular mechanism of lily-of-the-valley odorants detection in the Lilial and Bourgeonal family using the C/Si/Ge/Sn switch strategy.
    PLoS One. 2017 Aug 1;12(8):e0182147. doi: 10.1371/journal.pone.0182147. eCollection 2017.PubMed

  • Beltran LR, Dawid C, Beltran M, Levermann J, Titt S, Thomas S, Purschel V, Satalik M, Gisselmann G, Hofmann T, Hatt H
    The Effect of Pungent and Tingling Compounds from Piper nigrum L. on Background K(+) Currents.
    Front Pharmacol. 2017 Jun 26;8:408. doi: 10.3389/fphar.2017.00408. eCollection 2017.PubMed

  • Berger S, Hatt H, Ockenfels A
    Exposure to Hedione Increases Reciprocity in Humans.
    Front Behav Neurosci. 2017 May 2;11:79. doi: 10.3389/fnbeh.2017.00079. eCollection 2017.PubMed

  • Minovi A, Aguado A, Brunert D, Kurtenbach S, Dazert S, Hatt H, Conrad H
    Isolation, culture optimization and functional characterization of stem cell neurospheres from mouse neonatal olfactory bulb and epithelium.
    Eur Arch Otorhinolaryngol. 2017 Aug;274(8):3071-3085. doi: 10.1007/s00405-017-4590-z. Epub 2017 May 6.PubMed

  • Weber L, Al-Refae K, Ebbert J, Jagers P, Altmuller J, Becker C, Hahn S, Gisselmann G, Hatt H
    Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis.
    PLoS One. 2017 Mar 8;12(3):e0172491. doi: 10.1371/journal.pone.0172491. eCollection 2017.PubMed

  • Gelis L, Jovancevic N, Bechara FG, Neuhaus EM, Hatt H
    Functional expression of olfactory receptors in human primary melanoma and melanoma metastasis.
    Exp Dermatol. 2017 Jul;26(7):569-576. doi: 10.1111/exd.13316. Epub 2017 Apr 21.PubMed

  • Jovancevic N, Wunderlich KA, Haering C, Flegel C, Massberg D, Weinrich M, Weber L, Tebbe L, Kampik A, Gisselmann G, Wolfrum U, Hatt H, Gelis L
    Deep Sequencing of the Human Retinae Reveals the Expression of Odorant Receptors.
    Front Cell Neurosci. 2017 Jan 24;11:03. doi: 10.3389/fncel.2017.00003. eCollection 2017.PubMed

  • Jovancevic N, Dendorfer A, Matzkies M, Kovarova M, Heckmann JC, Osterloh M, Boehm M, Weber L, Nguemo F, Semmler J, Hescheler J, Milting H, Schleicher E, Gelis L, Hatt H
    Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor.
    Basic Res Cardiol. 2017 Mar;112(2):13. doi: 10.1007/s00395-017-0600-y. Epub 2017 Jan 23.PubMed

  • Veitinger S, Hatt H
    Ectopic Expression of Mammalian Olfactory Receptors
    Springer Handbook of Odor 2017 :691-709 doi:10.1007/978-3-319-26932-0 -> Journal Homepage

  • Weber LV, Al-Refae K, Wolk G, Bonatz G, Altmuller J, Becker C, Gisselmann G, Hatt H
    Expression and functionality of TRPV1 in breast cancer cells.
    Breast Cancer (Dove Med Press). 2016 Dec 13;8:243-252. doi: 10.2147/BCTT.S121610. eCollection 2016.PubMed

  • Kalbe B, Schulz VM, Schlimm M, Philippou S, Jovancevic N, Jansen F, Scholz P, Lubbert H, Jarocki M, Faissner A, Hecker E, Veitinger S, Tsai T, Osterloh S, Hatt H
    Helional-induced activation of human olfactory receptor 2J3 promotes apoptosis and inhibits proliferation in a non-small-cell lung cancer cell line.
    Eur J Cell Biol. 2017 Jan;96(1):34-46. doi: 10.1016/j.ejcb.2016.11.004. Epub 2016 Dec 5.PubMed

  • Kalbe B, Schlimm M, Wojcik S, Philippou S, Massberg D, Jansen F, Scholz P, Luebbert H, Ubrig B, Osterloh S, Hatt H
    Olfactory signaling components and olfactory receptors are expressed in tubule cells of the human kidney.
    Arch Biochem Biophys. 2016 Nov 15;610:8-15. doi: 10.1016/j.abb.2016.09.017. Epub 2016 Sep 28.PubMed

  • Walker J, Ley JP, Schwerzler J, Lieder B, Beltran L, Ziemba PM, Hatt H, Hans J, Widder S, Krammer GE, Somoza V
    Nonivamide, a capsaicin analogue, exhibits anti-inflammatory properties in peripheral blood mononuclear cells and U-937 macrophages.
    Mol Nutr Food Res. 2017 Feb;61(2). doi: 10.1002/mnfr.201600474. Epub 2016 Nov 15.PubMed

  • Flegel C, Vogel F, Hofreuter A, Wojcik S, Schoeder C, Kiec-Kononowicz K, Brockmeyer NH, Muller CE, Becker C, Altmuller J, Hatt H, Gisselmann G
    Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18.
    Sci Rep. 2016 Aug 30;6:32255. doi: 10.1038/srep32255.PubMed

  • Kalbe B, Schlimm M, Mohrhardt J, Scholz P, Jansen F, Hatt H, Osterloh S
    Helional induces Ca2+ decrease and serotonin secretion of QGP-1 cells via a PKG-mediated pathway.
    J Mol Endocrinol. 2016 Oct;57(3):201-10. doi: 10.1530/JME-16-0063. Epub 2016 Aug 23.PubMed

  • Manteniotis S, Wojcik S, Gothert JR, Durig J, Duhrsen U, Gisselmann G, Hatt H
    Deorphanization and characterization of the ectopically expressed olfactory receptor OR51B5 in myelogenous leukemia cells.
    Cell Death Discov. 2016 May 9;2:16010. doi: 10.1038/cddiscovery.2016.10. eCollection 2016.PubMed

  • Manteniotis S, Wojcik S, Brauhoff P, Mollmann M, Petersen L, Gothert JR, Schmiegel W, Duhrsen U, Gisselmann G, Hatt H
    Functional characterization of the ectopically expressed olfactory receptor 2AT4 in human myelogenous leukemia.
    Cell Death Discov. 2016 Jan 25;2:15070. doi: 10.1038/cddiscovery.2015.70. eCollection 2016.PubMed

  • Lehmann R, Hatt H, van Thriel C
    Alternative in vitro assays to assess the potency of sensory irritants-Is one TRP channel enough?
    Neurotoxicology. 2017 May;60:178-186. doi: 10.1016/j.neuro.2016.08.010. Epub 2016 Aug 18.PubMed

  • Kalbe B, Knobloch J, Schulz VM, Wecker C, Schlimm M, Scholz P, Jansen F, Stoelben E, Philippou S, Hecker E, Lubbert H, Koch A, Hatt H, Osterloh S
    Olfactory Receptors Modulate Physiological Processes in Human Airway Smooth Muscle Cells.
    Front Physiol. 2016 Aug 4;7:339. doi: 10.3389/fphys.2016.00339. eCollection 2016.PubMed

  • Hoffmann KM, Herbrechter R, Ziemba PM, Lepke P, Beltran L, Hatt H, Werner M, Gisselmann G
    Kampo Medicine: Evaluation of the Pharmacological Activity of 121 Herbal Drugs on GABAA and 5-HT3A Receptors.
    Front Pharmacol. 2016 Jul 29;7:219. doi: 10.3389/fphar.2016.00219. eCollection 2016.PubMed

  • Kanageswaran N, Nagel M, Scholz P, Mohrhardt J, Gisselmann G, Hatt H
    Modulatory Effects of Sex Steroids Progesterone and Estradiol on Odorant Evoked Responses in Olfactory Receptor Neurons.
    PLoS One. 2016 Aug 5;11(8):e0159640. doi: 10.1371/journal.pone.0159640. eCollection 2016PubMed

  • Massberg D, Jovancevic N, Offermann A, Simon A, Baniahmad A, Perner S, Pungsrinont T, Luko K, Philippou S, Ubrig B, Heiland M, Weber L, Altmuller J, Becker C, Gisselmann G, Gelis L, Hatt H
    The activation of OR51E1 causes growth suppression of human prostate cancer cells.
    Oncotarget. 2016 Jul 26;7(30):48231-48249. doi: 10.18632/oncotarget.10197.PubMed

  • Tsai T, Veitinger S, Peek I, Busse D, Eckardt J, Vladimirova D, Jovancevic N, Wojcik S, Gisselmann G, Altmuller J, Stander S, Luger T, Paus R, Cheret J, Hatt H
    Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation.
    Exp Dermatol. 2017 Jan;26(1):58-65. doi: 10.1111/exd.13132.PubMed

  • Gelis L, Jovancevic N, Veitinger S, Mandal B, Arndt HD, Neuhaus EM, Hatt H
    Functional Characterization of the Odorant Receptor 51E2 in Human Melanocytes.
    J Biol Chem. 2016 Aug 19;291(34):17772-86. doi: 10.1074/jbc.M116.734517. Epub 2016 May 18.PubMed

  • Hoffmann KM, Beltrán L, Ziemba PM, Hatt H, Gisselmann G
    Potentiating effect of glabridin from Glycyrrhizaglabra on GABAA receptors
    Biochemistry and Biophysics Reports 6(2016)197–202 -> Journal Homepage

  • Scholz P, Mohrhardt J, Jansen F, Kalbe B, Haering C, Klasen K, Hatt H, Osterloh S
    Identification of a Novel Gnao-Mediated Alternate Olfactory Signaling Pathway in Murine OSNs.
    Front Cell Neurosci. 2016 Mar 29;10:63. doi: 10.3389/fncel.2016.00063. eCollection 2016.PubMed

  • Lehmann R, Schobel N, Hatt H, van Thriel C
    The involvement of TRP channels in sensory irritation: a mechanistic approach toward a better understanding of the biological effects of local irritants.
    Arch Toxicol. 2016 Jun;90(6):1399-413. doi: 10.1007/s00204-016-1703-1. Epub 2016 Apr 1.PubMed

  • Croy I, Olgun S, Mueller L, Schmidt A, Muench M, Gisselmann G, Hatt H, Hummel T
    [Specific anosmia as a principle of olfactory perception].
    HNO. 2016 May;64(5):292-5. doi: 10.1007/s00106-016-0119-9.PubMed

  • Scholz P, Kalbe B, Jansen F, Altmueller J, Becker C, Mohrhardt J, Schreiner B, Gisselmann G, Hatt H, Osterloh S
    Transcriptome Analysis of Murine Olfactory Sensory Neurons during Development Using Single Cell RNA-Seq.
    Chem Senses. 2016 May;41(4):313-23. doi: 10.1093/chemse/bjw003. Epub 2016 Feb 2.PubMed

  • Flegel C, Vogel F, Hofreuter A, Schreiner BS, Osthold S, Veitinger S, Becker C, Brockmeyer NH, Muschol M, Wennemuth G, Altmuller J, Hatt H, Gisselmann G
    Characterization of the Olfactory Receptors Expressed in Human Spermatozoa.
    Front Mol Biosci. 2016 Jan 7;2:73. doi: 10.3389/fmolb.2015.00073. eCollection 2015.PubMed

  • Wallrabenstein I, Singer M, Panten J, Hatt H, Gisselmann G
    Timberol(R) Inhibits TAAR5-Mediated Responses to Trimethylamine and Influences the Olfactory Threshold in Humans.
    PLoS One. 2015 Dec 18;10(12):e0144704. doi: 10.1371/journal.pone.0144704. eCollection 2015.PubMed

  • Jansen F, Kalbe B, Scholz P, Mikosz M, Wunderlich KA, Kurtenbach S, Nagel-Wolfrum K, Wolfrum U, Hatt H, Osterloh S
    Impact of the Usher syndrome on olfaction.
    Hum Mol Genet. 2016 Feb 1;25(3):524-33. doi: 10.1093/hmg/ddv490. Epub 2015 Nov 29.PubMed

  • Croy I, Olgun S, Mueller L, Schmidt A, Muench M, Hummel C, Gisselmann G, Hatt H, Hummel T
    Peripheral adaptive filtering in human olfaction? Three studies on prevalence and effects of olfactory training in specific anosmia in more than 1600 participants.
    Cortex. 2015 Dec;73:180-7. doi: 10.1016/j.cortex.2015.08.018. Epub 2015 Sep 12.PubMed

  • Ziemba PM, Schreiner BS, Flegel C, Herbrechter R, Stark TD, Hofmann T, Hatt H, Werner M, Gisselmann G
    Activation and modulation of recombinantly expressed serotonin receptor type 3A by terpenes and pungent substances.
    Biochem Biophys Res Commun. 2015 Nov 27;467(4):1090-6. doi: 10.1016/j.bbrc.2015.09.074. Epub 2015 Oct 9.PubMed

  • Osterloh M, Bohm M, Kalbe B, Osterloh S, Hatt H
    Identification and functional characterization of TRPA1 in human myoblasts.
    Pflugers Arch. 2016 Feb;468(2):321-33. doi: 10.1007/s00424-015-1729-x. Epub 2015 Sep 2.PubMed

  • Herbrechter R, Ziemba PM, Hoffmann KM, Hatt H, Werner M, Gisselmann G
    Identification of Glycyrrhiza as the rikkunshito constituent with the highest antagonistic potential on heterologously expressed 5-HT3A receptors due to the action of flavonoids.
    Front Pharmacol. 2015 Jul 3;6:130. doi: 10.3389/fphar.2015.00130. eCollection 2015.PubMed

  • Sherkheli MA, Schreiner B, Haq R, Werner M, Hatt H
    Borneol inhibits TRPA1, a proinflammatory and noxious pain-sensing cation channel.
    Pak J Pharm Sci. 2015 Jul;28(4):1357-63.PubMed

  • Thiel U, Platt SJ, Wolf S, Hatt H, Gisselmann G
    Identification of amino acids involved in histamine potentiation of GABA A receptors.
    Front Pharmacol. 2015 May 26;6:106. doi: 10.3389/fphar.2015.00106. eCollection 2015.PubMed

  • Flegel C, Schobel N, Altmuller J, Becker C, Tannapfel A, Hatt H, Gisselmann G
    RNA-Seq Analysis of Human Trigeminal and Dorsal Root Ganglia with a Focus on Chemoreceptors.
    PLoS One. 2015 Jun 12;10(6):e0128951. doi: 10.1371/journal.pone.0128951. eCollection 2015.PubMed

  • Jansen F, Kalbe B, Scholz P, Franzel B, Osterloh M, Wolters D, Hatt H, Neuhaus EM, Osterloh S
    Biochemical Large-Scale Interaction Analysis of Murine Olfactory Receptors and Associated Signaling Proteins with Post-Synaptic Density 95, Drosophila Discs Large, Zona-Occludens 1 (PDZ) Domains.
    Mol Cell Proteomics. 2015 Aug;14(8):2072-84. doi: 10.1074/mcp.M114.045997. Epub 2015 May 15.PubMed

  • Wolf S, Hatt H, Ernst OP
    Does ketamine target olfactory receptors in the brain?
    Sci Signal. 2015 Mar 31;8(370):fs6. doi: 10.1126/scisignal.aab0600.PubMed

  • Wallrabenstein I, Gerber J, Rasche S, Croy I, Kurtenbach S, Hummel T, Hatt H
    The smelling of Hedione results in sex-differentiated human brain activity.
    Neuroimage. 2015 Jun;113:365-73. doi: 10.1016/j.neuroimage.2015.03.029. Epub 2015 Mar 19.PubMed

  • Haering C, Kanageswaran N, Bouvain P, Scholz P, Altmuller J, Becker C, Gisselmann G, Waring-Bischof J, Hatt H
    Ion transporter NKCC1, modulator of neurogenesis in murine olfactory neurons.
    J Biol Chem. 2015 Apr 10;290(15):9767-79. doi: 10.1074/jbc.M115.640656. Epub 2015 Feb 20.PubMed

  • Kanageswaran N, Demond M, Nagel M, Schreiner BS, Baumgart S, Scholz P, Altmuller J, Becker C, Doerner JF, Conrad H, Oberland S, Wetzel CH, Neuhaus EM, Hatt H, Gisselmann G
    Deep sequencing of the murine olfactory receptor neuron transcriptome.
    PLoS One. 2015 Jan 15;10(1):e0113170. doi: 10.1371/journal.pone.0113170. eCollection 2015.PubMed

  • Massberg D, Simon A, Haussinger D, Keitel V, Gisselmann G, Conrad H, Hatt H
    Monoterpene (-)-citronellal affects hepatocarcinoma cell signaling via an olfactory receptor.
    Arch Biochem Biophys. 2015 Jan 15;566:100-9. doi: 10.1016/j.abb.2014.12.004. Epub 2014 Dec 13.PubMed

  • Kurtenbach S, Whyte-Fagundes P, Gelis L, Kurtenbach S, Brazil E, Zoidl C, Hatt H, Shestopalov VI, Zoidl G
    Investigation of olfactory function in a Panx1 knock out mouse model.
    Front Cell Neurosci. 2014 Sep 12;8:266. doi: 10.3389/fncel.2014.00266. eCollection 2014.PubMed

  • Wiese H, Gelis L, Wiese S, Reichenbach C, Jovancevic N, Osterloh M, Meyer HE, Neuhaus EM, Hatt HH, Radziwill G, Warscheid B
    Quantitative phosphoproteomics reveals the protein tyrosine kinase Pyk2 as a central effector of olfactory receptor signaling in prostate cancer cells.
    Biochim Biophys Acta. 2015 Jun;1854(6):632-40. doi: 10.1016/j.bbapap.2014.09.002. Epub 2014 Sep 9.PubMed

  • Busse D, Kudella P, Gruning NM, Gisselmann G, Stander S, Luger T, Jacobsen F, Steinstrasser L, Paus R, Gkogkolou P, Bohm M, Hatt H, Benecke H
    A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4.
    J Invest Dermatol. 2014 Nov;134(11):2823-32. doi: 10.1038/jid.2014.273. Epub 2014 Jul 7.PubMed

  • Sondersorg AC, Busse D, Kyereme J, Rothermel M, Neufang G, Gisselmann G, Hatt H, Conrad H
    Chemosensory information processing between keratinocytes and trigeminal neurons.
    J Biol Chem. 2014 Jun 20;289(25):17529-40. doi: 10.1074/jbc.M113.499699. Epub 2014 May 1.PubMed

  • Kuhlmann K, Tschapek A, Wiese H, Eisenacher M, Meyer HE, Hatt HH, Oeljeklaus S, Warscheid B
    The membrane proteome of sensory cilia to the depth of olfactory receptors.
    Mol Cell Proteomics. 2014 Jul;13(7):1828-43. doi: 10.1074/mcp.M113.035378. Epub 2014 Apr 18.PubMed

  • Schobel N, Radtke D, Kyereme J, Wollmann N, Cichy A, Obst K, Kallweit K, Kletke O, Minovi A, Dazert S, Wetzel CH, Vogt-Eisele A, Gisselmann G, Ley JP, Bartoshuk LM, Spehr J, Hofmann T, Hatt H
    Astringency is a trigeminal sensation that involves the activation of G protein-coupled signaling by phenolic compounds.
    Chem Senses. 2014 Jul;39(6):471-87. doi: 10.1093/chemse/bju014. Epub 2014 Apr 9.PubMed

  • Baumgart S, Jansen F, Bintig W, Kalbe B, Herrmann C, Klumpers F, Koster SD, Scholz P, Rasche S, Dooley R, Metzler-Nolte N, Spehr M, Hatt H, Neuhaus EM
    The scaffold protein MUPP1 regulates odorant-mediated signaling in olfactory sensory neurons.
    J Cell Sci. 2014 Jun 1;127(Pt 11):2518-27. doi: 10.1242/jcs.144220. Epub 2014 Mar 20.PubMed

  • Schreiner BS, Lehmann R, Thiel U, Ziemba PM, Beltran LR, Sherkheli MA, Jeanbourquin P, Hugi A, Werner M, Gisselmann G, Hatt H
    Direct action and modulating effect of (+)- and (-)-nicotine on ion channels expressed in trigeminal sensory neurons.
    Eur J Pharmacol. 2014 Apr 5;728:48-58. doi: 10.1016/j.ejphar.2014.01.060. Epub 2014 Feb 7.PubMed

  • Beltran LR, Dawid C, Beltran M, Gisselmann G, Degenhardt K, Mathie K, Hofmann T, Hatt H
    The pungent substances piperine, capsaicin, 6-gingerol and polygodial inhibit the human two-pore domain potassium channels TASK-1, TASK-3 and TRESK.
    Front Pharmacol. 2013 Nov 18;4:141. doi: 10.3389/fphar.2013.00141. eCollection 2013.PubMed

  • Manteniotis S, Lehmann R, Flegel C, Vogel F, Hofreuter A, Schreiner BS, Altmuller J, Becker C, Schobel N, Hatt H, Gisselmann G
    Comprehensive RNA-Seq expression analysis of sensory ganglia with a focus on ion channels and GPCRs in Trigeminal ganglia.
    PLoS One. 2013 Nov 8;8(11):e79523. doi: 10.1371/journal.pone.0079523. eCollection 2013.PubMed

  • Lubbert M, Kyereme J, Schobel N, Beltran L, Wetzel CH, Hatt H
    Transient receptor potential channels encode volatile chemicals sensed by rat trigeminal ganglion neurons.
    PLoS One. 2013 Oct 21;8(10):e77998. doi: 10.1371/journal.pone.0077998. eCollection 2013.PubMed

  • Kurtenbach S, Wewering S, Hatt H, Neuhaus EM, Lubbert H
    Olfaction in three genetic and two MPTP-induced Parkinson's disease mouse models.
    PLoS One. 2013 Oct 30;8(10):e77509. doi: 10.1371/journal.pone.0077509. eCollection 2013.PubMed

  • Lubbert M, Kyereme J, Rothermel M, Wetzel CH, Hoffmann KP, Hatt H
    In vivo monitoring of chemically evoked activity patterns in the rat trigeminal ganglion.
    Front Syst Neurosci. 2013 Oct 8;7:64. doi: 10.3389/fnsys.2013.00064. eCollection 2013.PubMed

  • Hartmann C, Triller A, Spehr M,Dittrich R, Hatt H, Buettner A
    Sperm-Activating Odorous Substances in Human Follicular Fluid and Vaginal Secretion: Identification by Gas Chromatography–Olfactometry and Ca2+ Imaging
    ChemPlusChem, Volume 78, Issue 7, 695-702, July 2013 -> Journal Homepage

  • Beltran L, Beltran M, Aguado A, Gisselmann G, Hatt H
    2-Aminoethoxydiphenyl borate activates the mechanically gated human KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK), and KCNK 10 (TREK-2).
    Front Pharmacol. 2013 May 15;4:63. doi: 10.3389/fphar.2013.00063. eCollection 2013.PubMed

  • Kletke O, Gisselmann G, May A, Hatt H, A Sergeeva O
    Partial agonism of taurine at gamma-containing native and recombinant GABAA receptors.
    PLoS One. 2013 Apr 30;8(4):e61733. doi: 10.1371/journal.pone.0061733. Print 2013.PubMed

  • Geissler M, Gottschling C, Aguado A, Rauch U, Wetzel CH, Hatt H, Faissner A
    Primary hippocampal neurons, which lack four crucial extracellular matrix molecules, display abnormalities of synaptic structure and function and severe deficits in perineuronal net formation.
    J Neurosci. 2013 May 1;33(18):7742-55. doi: 10.1523/JNEUROSCI.3275-12.2013.PubMed

  • Sherkheli MA, Vogt-Eisele AK, Weber K, Hatt H
    Camphor modulates TRPV3 cation channels activity by interacting with critical pore-region cysteine residues.
    Pak J Pharm Sci. 2013 May;26(3):431-8.PubMed

  • Kletke O, Sergeeva OA, Lorenz P, Oberland S, Meier JC, Hatt H, Gisselmann G
    New insights in endogenous modulation of ligand-gated ion channels: histamine is an inverse agonist at strychnine sensitive glycine receptors.
    Eur J Pharmacol. 2013 Jun 15;710(1-3):59-66. doi: 10.1016/j.ejphar.2013.04.002. Epub 2013 Apr 17.PubMed

  • Flegel C, Manteniotis S, Osthold S, Hatt H, Gisselmann G
    Expression profile of ectopic olfactory receptors determined by deep sequencing.
    PLoS One. 2013;8(2):e55368. doi: 10.1371/journal.pone.0055368. Epub 2013 Feb 6.PubMed

  • Wallrabenstein I, Kuklan J, Weber L, Zborala S, Werner M, Altmuller J, Becker C, Schmidt A, Hatt H, Hummel T, Gisselmann G
    Human trace amine-associated receptor TAAR5 can be activated by trimethylamine.
    PLoS One. 2013;8(2):e54950. doi: 10.1371/journal.pone.0054950. Epub 2013 Feb 5.PubMed

  • Rollecke K, Werner M, Ziemba PM, Neuhaus EM, Hatt H, Gisselmann G
    Amiloride derivatives are effective blockers of insect odorant receptors.
    Chem Senses. 2013 Mar;38(3):231-6. doi: 10.1093/chemse/bjs140. Epub 2013 Jan 16.PubMed

  • Schobel N, Radtke D, Lubbert M, Gisselmann G, Lehmann R, Cichy A, Schreiner BS, Altmuller J, Spector AC, Spehr J, Hatt H, Wetzel CH
    Trigeminal ganglion neurons of mice show intracellular chloride accumulation and chloride-dependent amplification of capsaicin-induced responses.
    PLoS One. 2012;7(11):e48005. doi: 10.1371/journal.pone.0048005. Epub 2012 Nov 8.PubMed

  • Schobel N, Kyereme J, Minovi A, Dazert S, Bartoshuk L, Hatt H
    Sweet taste and chorda tympani transection alter capsaicin-induced lingual pain perception in adult human subjects.
    Physiol Behav. 2012 Oct 10;107(3):368-73. doi: 10.1016/j.physbeh.2012.09.004. Epub 2012 Sep 17.PubMed

  • Sherkheli MA, Gisselmann G, Hatt H
    Supercooling agent icilin blocks a warmth-sensing ion channel TRPV3.
    ScientificWorldJournal. 2012;2012:982725. doi: 10.1100/2012/982725. Epub 2012 Apr 1.PubMed

  • Klasen K, Hollatz D, Zielke S, Gisselmann G, Hatt H, Wetzel CH
    The TRPM8 ion channel comprises direct Gq protein-activating capacity.
    Pflugers Arch. 2012 Jun;463(6):779-97. doi: 10.1007/s00424-012-1098-7. Epub 2012 Mar 30.PubMed

  • Benecke H, Schneider SW, Lotts T, Hatt H, Luger TA, Stander S
    [Neuropeptides and their receptors as a molecular explanation for sensitive skin].
    Hautarzt. 2011 Dec;62(12):893-9. doi: 10.1007/s00105-011-2208-8.PubMed

  • Gelis L, Wolf S, Hatt H, Neuhaus EM, Gerwert K
    Prediction of a ligand-binding niche within a human olfactory receptor by combining site-directed mutagenesis with dynamic homology modeling.
    Angew Chem Int Ed Engl. 2012 Jan 27;51(5):1274-8. doi: 10.1002/anie.201103980. Epub 2011 Dec 5.PubMed

  • Yan L, Imbrosci B, Zhang W, Neubacher U, Hatt H, Eysel UT, Mittmann T
    Changes in NMDA-receptor function in the first week following laser-induced lesions in rat visual cortex.
    Cereb Cortex. 2012 Oct;22(10):2392-403. doi: 10.1093/cercor/bhr318. Epub 2011 Nov 16.PubMed

  • Hatt H, Dee R
    Wo Düfte ihren Anfang nehmen
    Gehirn und Geist, 2011(3), 38-41

  • Rothermel M, Ng BS, Grabska-Barwinska A, Hatt H, Jancke D
    Nasal chemosensory-stimulation evoked activity patterns in the rat trigeminal ganglion visualized by in vivo voltage-sensitive dye imaging.
    PLoS One. 2011;6(10):e26158. doi: 10.1371/journal.pone.0026158. Epub 2011 Oct 19.PubMed

  • Veitinger S, Veitinger T, Cainarca S, Fluegge D, Engelhardt CH, Lohmer S, Hatt H, Corazza S, Spehr J, Neuhaus EM, Spehr M
    Purinergic signalling mobilizes mitochondrial Ca(2)(+) in mouse Sertoli cells.
    J Physiol. 2011 Nov 1;589(Pt 21):5033-55. doi: 10.1113/jphysiol.2011.216309. Epub 2011 Aug 22.PubMed

  • Dooley R, Mashukova A, Toetter B, Hatt H, Neuhaus EM
    Purinergic receptor antagonists inhibit odorant-mediated CREB phosphorylation in sustentacular cells of mouse olfactory epithelium.
    BMC Neurosci. 2011 Aug 22;12:86. doi: 10.1186/1471-2202-12-86.PubMed

  • Kurtenbach S, Mayer C, Pelz T, Hatt H, Leese F, Neuhaus EM
    Molecular evolution of a chordate specific family of G protein-coupled receptors.
    BMC Evol Biol. 2011 Aug 9;11:234. doi: 10.1186/1471-2148-11-234.PubMed

  • Yanovsky Y, Schubring S, Fleischer W, Gisselmann G, Zhu XR, Lubbert H, Hatt H, Rudolph U, Haas HL, Sergeeva OA
    GABAA receptors involved in sleep and anaesthesia: beta1- versus beta3-containing assemblies.
    Pflugers Arch. 2012 Jan;463(1):187-99. doi: 10.1007/s00424-011-0988-4. Epub 2011 Jul 7.PubMed

  • Anselmi C, Buonocore A, Centini M, Facino RM, Hatt H
    The human olfactory receptor 17-40: requisites for fitting into the binding pocket.
    Comput Biol Chem. 2011 Jun;35(3):159-68. doi: 10.1016/j.compbiolchem.2011.04.011. Epub 2011 May 4.PubMed

  • Hummel T, Schultz S, Witt M, Hatt H
    Electrical responses to chemosensory stimulation recorded from the vomeronasal duct and the respiratory epithelium in humans.
    Int J Psychophysiol. 2011 Aug;81(2):116-20. doi: 10.1016/j.ijpsycho.2011.05.002. Epub 2011 May 25.PubMed

  • Pyka M, Wetzel C, Aguado A, Geissler M, Hatt H, Faissner A
    Chondroitin sulfate proteoglycans regulate astrocyte-dependent synaptogenesis and modulate synaptic activity in primary embryonic hippocampal neurons.
    Eur J Neurosci. 2011 Jun;33(12):2187-202. doi: 10.1111/j.1460-9568.2011.07690.x. Epub 2011 May 25.PubMed

  • Steinstraesser L, Hauk J, Schubert C, Al-Benna S, Stricker I, Hatt H, Shai Y, Steinau HU, Jacobsen F
    Suppression of soft tissue sarcoma growth by a host defense-like lytic peptide.
    PLoS One. 2011 Mar 31;6(3):e18321. doi: 10.1371/journal.pone.0018321.PubMed

  • Veitinger T, Riffell JR, Veitinger S, Nascimento JM, Triller A, Chandsawangbhuwana C, Schwane K, Geerts A, Wunder F, Berns MW, Neuhaus EM, Zimmer RK, Spehr M, Hatt H
    Chemosensory Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm.
    J Biol Chem. 2011 May 13;286(19):17311-25. doi: 10.1074/jbc.M110.211524. Epub 2011 Mar 21.PubMed

  • Spehr J, Gelis L, Osterloh M, Oberland S, Hatt H, Spehr M, Neuhaus EM
    G protein-coupled receptor signaling via Src kinase induces endogenous human transient receptor potential vanilloid type 6 (TRPV6) channel activation.
    J Biol Chem. 2011 Apr 15;286(15):13184-92. doi: 10.1074/jbc.M110.183525. Epub 2011 Feb 24.PubMed

  • Doerner JF, Hatt H, Ramsey IS
    Voltage- and temperature-dependent activation of TRPV3 channels is potentiated by receptor-mediated PI(4,5)P2 hydrolysis.
    J Gen Physiol. 2011 Mar;137(3):271-88. doi: 10.1085/jgp.200910388. Epub 2011 Feb 14.PubMed

  • Bredendiek N, Hutte J, Steingraber A, Hatt H, Gisselmann G, Neuhaus EM
    Go alpha is involved in sugar perception in Drosophila.
    Chem Senses. 2011 Jan;36(1):69-81. doi: 10.1093/chemse/bjq100. Epub 2010 Oct 12.PubMed

  • Sherkheli MA, Vogt-Eisele AK, Bura D, Beltran Marques LR, Gisselmann G, Hatt H
    Characterization of selective TRPM8 ligands and their structure activity response (S.A.R) relationship.
    J Pharm Pharm Sci. 2010;13(2):242-53.PubMed

  • Steinstraesser L, Schubert C, Hauk J, Becerikli M, Stricker I, Koeller M, Hatt H, von Duering M, Shai Y, Steinau HU, Jacobsen F
    Oncolytic designer host defense peptide suppresses growth of human liposarcoma.
    Int J Cancer. 2011 Jun 15;128(12):2994-3004. doi: 10.1002/ijc.25627. Epub 2010 Nov 23.PubMed

  • Kueper T, Krohn M, Haustedt LO, Hatt H, Schmaus G, Vielhaber G
    Inhibition of TRPV1 for the treatment of sensitive skin.
    Exp Dermatol. 2010 Nov;19(11):980-6. doi: 10.1111/j.1600-0625.2010.01122.x.PubMed

  • Cohen SP, Haack KK, Halstead-Nussloch GE, Bernard KF, Hatt H, Kubanek J, McCarty NA
    Identification of RL-TGR, a coreceptor involved in aversive chemical signaling.
    Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12339-44. doi: 10.1073/pnas.1000343107. Epub 2010 Jun 21.PubMed

  • Sergeeva OA, Kletke O, Kragler A, Poppek A, Fleischer W, Schubring SR, Gorg B, Haas HL, Zhu XR, Lubbert H, Gisselmann G, Hatt H
    Fragrant dioxane derivatives identify beta1-subunit-containing GABAA receptors.
    J Biol Chem. 2010 Jul 30;285(31):23985-93. doi: 10.1074/jbc.M110.103309. Epub 2010 May 28.PubMed

  • Rothermel M, Brunert D, Klupp BG, Luebbert M, Mettenleiter TC, Hatt H
    Advanced tracing tools: functional neuronal expression of virally encoded fluorescent calcium indicator proteins.
    J Neurovirol. 2009 Sep;15(5-6):458-64. doi: 10.3109/13550280903473460.PubMed

  • Rasche S, Toetter B, Adler J, Tschapek A, Doerner JF, Kurtenbach S, Hatt H, Meyer H, Warscheid B, Neuhaus EM
    Tmem16b is specifically expressed in the cilia of olfactory sensory neurons.
    Chem Senses. 2010 Mar;35(3):239-45. doi: 10.1093/chemse/bjq007. Epub 2010 Jan 25.PubMed

  • Luebbert M, Radtke D, Wodarski R, Damann N, Hatt H, Wetzel CH
    Direct activation of transient receptor potential V1 by nickel ions.
    Pflugers Arch. 2010 Apr;459(5):737-50. doi: 10.1007/s00424-009-0782-8. Epub 2010 Jan 26.PubMed

  • Minovi A, Witt M, Prescher A, Gudziol V, Dazert S, Hatt H, Benecke H
    Expression and distribution of the intermediate filament protein nestin and other stem cell related molecules in the human olfactory epithelium.
    Histol Histopathol. 2010 Feb;25(2):177-87. doi: 10.14670/HH-25.177.PubMed

  • Dooley R, Baumgart S, Rasche S, Hatt H, Neuhaus EM
    Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1.
    FEBS J. 2009 Dec;276(24):7279-90. doi: 10.1111/j.1742-4658.2009.07435.x.PubMed

  • Klasen K, Corey EA, Kuck F, Wetzel CH, Hatt H, Ache BW
    Odorant-stimulated phosphoinositide signaling in mammalian olfactory receptor neurons.
    Cell Signal. 2010 Jan;22(1):150-7. doi: 10.1016/j.cellsig.2009.09.026. Epub 2009 Sep 22.PubMed

  • Sherkheli MA, Benecke H, Doerner JF, Kletke O, Vogt-Eisele AK, Gisselmann G, Hatt H
    Monoterpenoids induce agonist-specific desensitization of transient receptor potential vanilloid-3 (TRPV3) ion channels.
    J Pharm Pharm Sci. 2009;12(1):116-28.PubMed

  • Brunert D, Kurtenbach S, Isik S, Benecke H, Gisselmann G, Schuhmann W, Hatt H, Wetzel CH
    Odorant-dependent generation of nitric oxide in Mammalian olfactory sensory neurons.
    PLoS One. 2009;4(5):e5499. doi: 10.1371/journal.pone.0005499. Epub 2009 May 11.PubMed

  • Neuhaus EM, Zhang W, Gelis L, Deng Y, Noldus J, Hatt H
    Activation of an olfactory receptor inhibits proliferation of prostate cancer cells.
    J Biol Chem. 2009 Jun 12;284(24):16218-25. doi: 10.1074/jbc.M109.012096. Epub 2009 Apr 23.PubMed

  • Hatt HG G, Ak VE, Jf D, H H
    Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels.
    Pak J Pharm Sci. 2008 Oct;21(4):370-8.PubMed

  • Triller A, Boulden EA, Churchill A, Hatt H, Englund J, Spehr M, Sell CS
    Odorant-receptor interactions and odor percept: a chemical perspective.
    Chem Biodivers. 2008 Jun;5(6):862-86. doi: 10.1002/cbdv.200890101.PubMed

  • Neuhaus EM, Hatt H
    Mimicking the olfactory system for the classification of chemical data.
    Trends Biotechnol. 2008 Jul;26(7):347-9. doi: 10.1016/j.tibtech.2008.03.009. Epub 2008 May 9.PubMed

  • Barbour J, Neuhaus EM, Piechura H, Stoepel N, Mashukova A, Brunert D, Sitek B, Stuhler K, Meyer HE, Hatt H, Warscheid B
    New insight into stimulus-induced plasticity of the olfactory epithelium in Mus musculus by quantitative proteomics.
    J Proteome Res. 2008 Apr;7(4):1594-605. doi: 10.1021/pr7005796. Epub 2008 Mar 13.PubMed

  • Saras A, Gisselmann G, Vogt-Eisele AK, Erlkamp KS, Kletke O, Pusch H, Hatt H
    Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses.
    J Biol Chem. 2008 Apr 18;283(16):10470-5. doi: 10.1074/jbc.M709993200. Epub 2008 Feb 15.PubMed

  • Cohen SA, Hatt H, Kubanek J, McCarty NA
    Reconstitution of a chemical defense signaling pathway in a heterologous system.
    J Exp Biol. 2008 Feb;211(Pt 4):599-605. doi: 10.1242/jeb.009225.PubMed

  • Rothermel M, Schobel N, Damann N, Klupp BG, Mettenleiter TC, Hatt H, Wetzel CH
    Anterograde transsynaptic tracing in the murine somatosensory system using Pseudorabies virus (PrV): a "live-cell"-tracing tool for analysis of identified neurons in vitro.
    J Neurovirol. 2007 Dec;13(6):579-85.PubMed

  • Powers DB, Will MJ, Bourgeois SL Jr, Hatt HD
    Maxillofacial trauma treatment protocol.
    Oral Maxillofac Surg Clin North Am. 2005 Aug;17(3):341-55, vii.PubMed

  • Buchwald B, Zhang G, Vogt-Eisele AK, Zhang W, Ahangari R, Griffin JW, Hatt H, Toyka KV, Sheikh KA
    Anti-ganglioside antibodies alter presynaptic release and calcium influx.
    Neurobiol Dis. 2007 Oct;28(1):113-21. Epub 2007 Jul 14.PubMed

  • Vogt-Eisele AK, Weber K, Sherkheli MA, Vielhaber G, Panten J, Gisselmann G, Hatt H
    Monoterpenoid agonists of TRPV3.
    Br J Pharmacol. 2007 Jun;151(4):530-40. Epub 2007 Apr 10.PubMed

  • Doszczak L, Kraft P, Weber HP, Bertermann R, Triller A, Hatt H, Tacke R
    Prediction of perception: probing the hOR17-4 olfactory receptor model with silicon analogues of bourgeonal and lilial.
    Angew Chem Int Ed Engl. 2007;46(18):3367-71.PubMed

  • Doerner JF, Gisselmann G, Hatt H, Wetzel CH
    Transient receptor potential channel A1 is directly gated by calcium ions.
    J Biol Chem. 2007 May 4;282(18):13180-9. Epub 2007 Mar 12.PubMed

  • Doszczak L, Kraft P, Weber H.-P, Bertermann R, Triller A, Hatt H, Tacke R
    Duftvorhersage: das Computermodell des hOR17-4-Rezeptors auf dem Prüfstand mit Silicium-Analoga von Bourgeonal und Lilial
    Angew. Chem. (2007) 119: 1-7 -> Journal Homepage

  • Hatt H, Wetzel Ch
    Geruch oder Geschmack? Kohlendioxid-Wahrnehmung durch multiple Systeme
    Naturwiss. Rundschau (2007) 12: 651-652

  • Hatt H
    Molecular and cellular basis of human olfaction.
    Chem Biodivers. 2004 Dec;1(12):1857-69.PubMed

  • Mashukova A, Spehr M, Hatt H, Neuhaus EM
    Beta-arrestin2-mediated internalization of mammalian odorant receptors.
    J Neurosci. 2006 Sep 27;26(39):9902-12.PubMed

  • Michalakis S, Reisert J, Geiger H, Wetzel C, Zong X, Bradley J, Spehr M, Huttl S, Gerstner A, Pfeifer A, Hatt H, Yau KW, Biel M
    Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping.
    J Biol Chem. 2006 Nov 17;281(46):35156-66. Epub 2006 Sep 15.PubMed

  • Neuhaus EM, Mashukova A, Barbour J, Wolters D, Hatt H
    Novel function of beta-arrestin2 in the nucleus of mature spermatozoa.
    J Cell Sci. 2006 Aug 1;119(Pt 15):3047-56. Epub 2006 Jul 4.PubMed

  • Bastian P, Posch B, Lang K, Niggemann B, Zaenker KS, Hatt H, Entschladen F
    Phosphatidylinositol 3-kinase in the G protein-coupled receptor-induced chemokinesis and chemotaxis of MDA-MB-468 breast carcinoma cells: a comparison with leukocytes.
    Mol Cancer Res. 2006 Jun;4(6):411-21.PubMed

  • Damann N, Rothermel M, Klupp BG, Mettenleiter TC, Hatt H, Wetzel CH
    Chemosensory properties of murine nasal and cutaneous trigeminal neurons identified by viral tracing.
    BMC Neurosci. 2006 Jun 8;7:46.PubMed

  • Damann N, Klopfleisch R, Rothermel M, Doerner JF, Mettenleiter TC, Hatt H, Wetzel CH
    Neuronal pathways of viral invasion in mice after intranasal inoculation of pseudorabies virus PrV-9112C2 expressing bovine herpesvirus 1 glycoprotein B.
    J Neurovirol. 2006 Feb;12(1):60-4.PubMed

  • Neuhaus EM, Mashukova A, Zhang W, Barbour J, Hatt H
    A specific heat shock protein enhances the expression of mammalian olfactory receptor proteins.
    Chem Senses. 2006 Jun;31(5):445-52. Epub 2006 Mar 24.PubMed

  • Spehr M, Schwane K, Riffell JA, Zimmer RK, Hatt H
    Odorant receptors and olfactory-like signaling mechanisms in mammalian sperm.
    Mol Cell Endocrinol. 2006 May 16;250(1-2):128-36. Epub 2006 Jan 18.PubMed

  • Spehr M, Hatt H
    A potential role of odorant receptor agonists and antagonists in the treatment of infertility and contraception.
    Curr Opin Investig Drugs. 2005 Apr;6(4):364-8.PubMed

  • Gisselmann G, Marx T, Bobkov Y, Wetzel CH, Neuhaus EM, Ache BW, Hatt H
    Molecular and functional characterization of an I(h)-channel from lobster olfactory receptor neurons.
    Eur J Neurosci. 2005 Mar;21(6):1635-47.PubMed

  • Gisselmann G, Gamerschlag B, Sonnenfeld R, Marx T, Neuhaus EM, Wetzel CH, Hatt H
    Variants of the Drosophila melanogaster Ih-channel are generated by different splicing.
    Insect Biochem Mol Biol. 2005 May;35(5):505-14.PubMed

  • Wetzel CH, Brunert D, Hatt H
    Cellular mechanisms of olfactory signal transduction.
    Chem Senses. 2005 Jan;30 Suppl 1:i321-2.PubMed

  • Schnizler K, Saeger B, Pfeffer C, Gerbaulet A, Ebbinghaus-Kintscher U, Methfessel C, Franken EM, Raming K, Wetzel CH, Saras A, Pusch H, Hatt H, Gisselmann G
    A novel chloride channel in Drosophila melanogaster is inhibited by protons.
    J Biol Chem. 2005 Apr 22;280(16):16254-62. Epub 2005 Feb 15.PubMed

  • Zhainazarov AB, Spehr M, Wetzel CH, Hatt H, Ache BW
    Modulation of the olfactory CNG channel by Ptdlns(3,4,5)P3.
    J Membr Biol. 2004 Sep 1;201(1):51-7.PubMed

  • Neuhaus E, Hatt H
    Heterodimerisierung von Geruchsrezeptoren der Taufliege
    Naturwiss. Rundschau (2005) 58: 276-278

  • Neuhaus EM, Gisselmann G, Zhang W, Dooley R, Stortkuhl K, Hatt H
    Odorant receptor heterodimerization in the olfactory system of Drosophila melanogaster.
    Nat Neurosci. 2005 Jan;8(1):15-7. Epub 2004 Dec 12.PubMed

  • Hatt H
    [Nobel Prize for Medicine 2004. Olfaction: "lower sense" achieves high significance].
    Dtsch Med Wochenschr. 2004 Nov 12;129(46):2458-60.PubMed

  • Hatt H
    [2004 Nobel Prize for Medicine. A good sense of smell for the entire body (interview by Dr. T. Meissner)].
    MMW Fortschr Med. 2004 Oct 14;146(42):17.PubMed

  • Gisselmann G, Plonka J, Pusch H, Hatt H
    Unusual functional properties of homo- and heteromultimeric histamine-gated chloride channels of Drosophila melanogaster: spontaneous currents and dual gating by GABA and histamine.
    Neurosci Lett. 2004 Nov 30;372(1-2):151-6.PubMed

  • Spehr M, Schwane K, Heilmann S, Gisselmann G, Hummel T, Hatt H
    Dual capacity of a human olfactory receptor.
    Curr Biol. 2004 Oct 5;14(19):R832-3.PubMed

  • Gisselmann G, Wetzel CH, Warnstedt M, Hatt H
    Functional characterization of Ih-channel splice variants from Apis mellifera.
    FEBS Lett. 2004 Sep 24;575(1-3):99-104.PubMed

  • Spehr M, Schwane K, Riffell JA, Barbour J, Zimmer RK, Neuhaus EM, Hatt H
    Particulate adenylate cyclase plays a key role in human sperm olfactory receptor-mediated chemotaxis.
    J Biol Chem. 2004 Sep 17;279(38):40194-203. Epub 2004 Jul 22.PubMed

  • Spehr M, Hatt H
    hOR17-4 as a potential therapeutic target.
    Drug News Perspect. 2004 Apr;17(3):165-71.PubMed

  • Gisselmann G, Plonka J, Pusch H, Hatt H
    Drosophila melanogaster GRD and LCCH3 subunits form heteromultimeric GABA-gated cation channels.
    Br J Pharmacol. 2004 Jun;142(3):409-13. Epub 2004 May 17.PubMed

  • Spehr J, Spehr M, Hatt H, Wetzel CH
    Subunit-specific P2X-receptor expression defines chemosensory properties of trigeminal neurons.
    Eur J Neurosci. 2004 May;19(9):2497-510.PubMed

  • Behrendt HJ, Germann T, Gillen C, Hatt H, Jostock R
    Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay.
    Br J Pharmacol. 2004 Feb;141(4):737-45. Epub 2004 Feb 2.PubMed

  • Hatt H
    Molecular and cellular basis of human olfaction
    Chem. & Biodiv. (2004) 1: 1857-1869

  • Hatt H
    Riechen: Ein niederer Sinn erlangt hohe Bedeutung
    DMW Praxis 9: (2004) 353-55

  • Hatt H
    Physiologie oder Medizin
    Naturwiss. Rundschau (2004): 676-677

  • Hatt H
    Doppelfunktion von Riechrezeptoren in Nase und Spermien
    Bioforum (2004) 12: 2-4

  • Gisselmann G, Warnstedt M, Gamerschlag B, Bormann A, Marx T, Neuhaus EM, Stoertkuhl K, Wetzel CH, Hatt H
    Characterization of recombinant and native Ih-channels from Apis mellifera.
    Insect Biochem Mol Biol. 2003 Nov;33(11):1123-34.PubMed

  • Zhang Y, Oliva R, Gisselmann G, Hatt H, Guckenheimer J, Harris-Warrick RM
    Overexpression of a hyperpolarization-activated cation current (Ih) channel gene modifies the firing activity of identified motor neurons in a small neural network.
    J Neurosci. 2003 Oct 8;23(27):9059-67.PubMed

  • Lang K, Hatt H, Niggemann B, Zaenker KS, Entschladen F
    A novel function for chemokines: downregulation of neutrophil migration.
    Scand J Immunol. 2003 Apr;57(4):350-61.PubMed

  • Spehr M, Gisselmann G, Poplawski A, Riffell JA, Wetzel CH, Zimmer RK, Hatt H
    Identification of a testicular odorant receptor mediating human sperm chemotaxis.
    Science. 2003 Mar 28;299(5615):2054-8.PubMed

  • Marx T, Gisselmann G, Stortkuhl KF, Hovemann BT, Hatt H
    Molecular cloning of a putative voltage- and cyclic nucleotide-gated ion channel present in the antennae and eyes of Drosophila melanogaster.
    Invert Neurosci. 1999-2000;4(1):55-63.PubMed

  • Spehr M, Hatt H, Wetzel CH
    Arachidonic acid plays a role in rat vomeronasal signal transduction.
    J Neurosci. 2002 Oct 1;22(19):8429-37.PubMed

  • Gisselmann G, Galler A, Friedrich F, Hatt H, Bormann J
    Cloning and functional characterization of two glycine receptor alpha-subunits from the perch retina.
    Eur J Neurosci. 2002 Jul;16(1):69-80.PubMed

  • Mohrmann R, Kohr G, Hatt H, Sprengel R, Gottmann K
    Deletion of the C-terminal domain of the NR2B subunit alters channel properties and synaptic targeting of N-methyl-D-aspartate receptors in nascent neocortical synapses.
    J Neurosci Res. 2002 May 1;68(3):265-75.PubMed

  • Kroner S, Gottmann K, Hatt H, Gunturkun O
    Electrophysiological and morphological properties of cell types in the chick neostriatum caudolaterale.
    Neuroscience. 2002;110(3):459-73.PubMed

  • Spehr M, Wetzel CH, Hatt H, Ache BW
    3-phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neurons.
    Neuron. 2002 Feb 28;33(5):731-9.PubMed

  • Hatt H, Gisselmann G, Pusch H
    Histamingesteuerte Ionenkanal im Fliegenauge
    Naturwiss. Rundschau (2002): 268-269

  • Gisselmann G, Pusch H, Hovemann BT, Hatt H
    Two cDNAs coding for histamine-gated ion channels in D. melanogaster.
    Nat Neurosci. 2002 Jan;5(1):11-2.PubMed

  • Wetzel CH, Spehr M, Hatt H
    Phosphorylation of voltage-gated ion channels in rat olfactory receptor neurons.
    Eur J Neurosci. 2001 Oct;14(7):1056-64.PubMed

  • Hatt H, Lang K, Gisselmann G
    Functional expression and characterization of odorant receptors using the Semliki Forest virus system.
    Biol Chem. 2001 Aug;382(8):1207-14.PubMed

  • Wetzel CH, Behrendt HJ, Gisselmann G, Stortkuhl KF, Hovemann B, Hatt H
    Functional expression and characterization of a Drosophila odorant receptor in a heterologous cell system.
    Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9377-80.PubMed

  • Lobitz N, Gisselmann G, Hatt H, Wetzel CH
    A single amino-acid in the TM1 domain is an important determinant of the desensitization kinetics of recombinant human and guinea pig alpha-homomeric 5-hydroxytryptamine type 3 receptors.
    Mol Pharmacol. 2001 Apr;59(4):844-51.PubMed

  • Rumpel S, Hoffmann H, Hatt H, Gottmann K, Mittmann T, Eysel UT
    Lesion-induced changes in NMDA receptor subunit mRNA expression in rat visual cortex.
    Neuroreport. 2000 Dec 18;11(18):4021-5.PubMed

  • Hatt H, Gisselmann G, Spehr M, Wetzel Ch
    Functional expression and characterization of human olfactory receptor proteins
    J. Biol. Chem. (2001) 382: 180-182

  • Hoffmann H, Gremme T, Hatt H, Gottmann K
    Synaptic activity-dependent developmental regulation of NMDA receptor subunit expression in cultured neocortical neurons.
    J Neurochem. 2000 Oct;75(4):1590-9.PubMed

  • Mohrmann R, Hatt H, Gottmann K
    Developmental regulation of subunit composition of extrasynaptic NMDA receptors in neocortical neurones.
    Neuroreport. 2000 Apr 27;11(6):1203-8.PubMed

  • Lankiewicz S, Huser MB, Heumann R, Hatt H, Gisselmann G
    Phosphorylation of the 5-hydroxytryptamine3 (5-HT3) receptor expressed in HEK293 cells.
    Receptors Channels. 2000;7(1):9-15.PubMed