Publications since 1997

• Triller A., Boulden E.A., Churchill A., Hatt H., Englund J., Spehr M., Sell C.S. (2008) Odorant-receptor interactions and odor percept: a chemical perspective. Chem. and Biodivers. 5(6): 862-886
   

• Neuhaus E.M., Hatt, H. (2008) Mimicking the olfactory system for the classification of chemical data. Trends Biotechnol. 26(7): 347-349
   

• Saras A., Gisselmann G., Vogt-Eisele A.K., Erlkamp K.S., Kletke O., Pusch H., Hatt H. (2008) Histamine action on vertebrate GABA(A) receptors: direct channel gating and potentiation of GABA-responses. J. Biol. Chem. 283: 10470-10475
   

• Barbour J., Neuhaus E.M., Piechura H., Stoepel N., Mashukova A., Brunert D., Sitek B., Stühler K., Meyer H., Hatt H., Warscheid B. (2008) New insight into stimulus-induced plasticity of the olfactory epithelium in Mus Musculus by quantitative proteomics. J. Proteome Res. 7(4): 1594-1605
   

• Cohen SAP, Hatt H, Kubanek J, McCarty NA (2008) Reconstitution of a chemical defense signaling pathway in a heterologous system. J Exp Biol 211: 599-605
   

• Vogt-Eisele A.K., Weber K., Sherkheli M.A., Vielhaber G., Panten J., Gisselmann G., Hatt H. (2007) Monoterpenoid agonists of TRPV3. British J. Pharmacol. 151: 530-540
   

• Rothermel M., Schöbel N., Damann N., Klupp B.G., Mettenleiter T.C., Hatt H., Wetzel C.H. (2007) Anterograde transsynaptic tracing in the murine somatosensory system using Pseudorabies virus (PrV): A "live-cell"-tracing tool for analysis of identified neurons in vitro. J Neurovirol 13: 579-585
   

• Hatt H., Wetzel Ch. (2007) Geruch oder Geschmack? Kohlendioxid-Wahrnehmung durch multiple Systeme. Naturwiss. Rundschau 12: 651-652.
   

• Doszczak L., Kraft P., Weber H.-P., Bertermann R., Triller A., Hatt H. und Tacke R. (2007) Duftvorhersage: das Computermodell des hOR17-4-Rezeptors auf dem Prüfstand mit Silicium-Analoga von Bourgeonal und Lilial. Angew. Chem. 119: 1-7
   

• Doszczak L., Kraft P., Weber H.-P., Bertermann R., Triller A., Hatt H., and Tacke R. (2007) Prediction of Perception: Probing the hOR17-4 Olfactory Receptor Model with Silicon Analogues of Bourgeonal and Lilial. Angew. Chem. Int. Ed. 46: 3367-3371
   

• Dörner J.F., Gisselmann G., Hatt H., Wetzel CH. (2007) Transient receptor potential channel A1 is directly gated by calcium ions. J. Biol. Chem. 282: 13180-13189
   

• Buchwald B., Zhang G., Vogt-Eisele A.K., Zhang W., Ahangari R., Griffin J.W., Hatt H., Toyka K.V., Sheikh K.A. (2007) Anti-ganglioside antibodies alter presynaptic release and calcium influx, Neurobiol. Dis. 1: 113-121
   

• Michalakis S., Reisert J., Geiger H., Wetzel CH., Zong X., Bradley J., Spehr M., Hüttl S., Gerstner A., Pfeifer A., Hatt H., Yau K.-W., Biel M. (2006) Loss of CNGB1 protein leads to olfactory dysfunction and subciliary CNG channel trapping. J. Biol. Chem. accepted 15.09.06
   

• Mashukova A., Hatt H., Neuhaus E.M. (2006) ß-arrestin2 mediated internalization of mammalian odorant receptors. J. Neurosci. 26: 9902-9912
   

• Spehr M., Schwane K., Riffell J.A., Zimmer R.K., Hatt, H. (2006) Odorant receptors and olfactory-like signaling mechanisms in mammalian sperm. Mol. Cell. Endocrinol. 250: 128-136
   

• Neuhaus, E.M., Mashukova, A., Barbour,J., Wolters, D., Hatt, H. (2006). Novel function of ß-arrestin2 in the nucleus of mature spermatozoa. J. Cell Sci. 119: 3047-3056
   

• Neuhaus, E.M., Mashukova, A., Zhang, W., Barbour, J., Hatt, H. (2006). A specific heat shock protein enhances the expression of mammalian olfactory receptor proteins. Chem. Senses 31, 445-452
   

• Damann N., Klopfleisch R., Rothermel M., Dörner J.F., Mettenleiter T.C., Hatt H., Wetzel CH. (2006) Neuronal pathways of viral invasion in mice after intranasal inoculation of pseudorabies virus PrV-9112C2 expressing bovine herpesvirus 1 glycoprotein B. J. Neurovirol. 12: 60-64
   

• Damann N., Rothermel M., Klupp B. G., Mettenleiter T.C., Hatt H., Wetzel CH. (2006) Chemosensory properties of murine nasal and cutaneous trigeminal neurons identified by viral tracing. BMC Neurosci.; 7: 46
   

• Bastian P., Posch B., Lang K., Niggemann B., Zaenker K.S., Hatt H., Entschladen F. (2006) Phosphatidylinositol 3-kinase in the G protein-coupled receptor-induced chemokinesis and chemotaxis of MDA-MB-468 breast carciinoma cells: a comparison with leukocytes. Mol. Cancer Res. 4: 411-421
   

• Wetzel C.H., Brunert D., Hatt H. (2005) Cellular mechanisms of olfactory signal transduction. Chem. Senses 30, 1: i321-i322
   

• Spehr M., Hatt H. (2005) A potential role of odorant receptor agonists and antagonists in the treatment of infertility and contraception. Curr. Opin. Invest. Drugs 6(4): 364-368
   

• Schnizler K., Saeger B., Pfeffer C., Gerbaulet A., Ebbinghaus-Kintscher U., Methfessel C., Franken E.M., Raming K., Wetzel C.H., Saras A, Pusch H, Hatt H., Gisselmann G. (2005) A novel chloride channel in Drosophila melanogaster is inhibited by protons. J. Biol. Chem. 280(16): 16254-16262

• Neuhaus E., Hatt H. (2005) Heterodimerisierung von Geruchsrezeptoren der Taufliege. Naturwiss. Rundschau 58: 276-278

• Wetzel C.H., Brunert D., Hatt H. (2005) Cellular mechanisms of olfactory signal transduction. Chem. Senses 30, i321-i322

• Schnizler K., Saeger B., Pfeffer C., Gerbaulet A., Ebbinghaus-Kintscher U., Methfessel C., Franken E.M., Raming K., Wetzel C.H., Saras A, Pusch H, Hatt H., Gisselmann G. (2005) A novel chloride channel in Drosophila melanogaster is inhibited by protons. J. Biol. Chem. 280(16): 16254-16262

• Gisselmann G., Gamerschlag B., Sonnenfeld R., Marx T., Neuhaus E.M., Wetzel C.H., Hatt H. (2005) Variants of the Drosophila melanogaster Ih-channel are generated by different splicing. Insect Biochem. Mol. Biol. 35(5): 505-514

• Gisselmann G., Marx T., Bobkov Y., Wetzel C.H., Neuhaus E.M., Ache B. W. Hatt H. (2005) Molecular and functional characterization of an Ih-channel from lobster olfactory receptor neurons. Eur. J. Neurosci. 21(6): 1635-1647

• Spehr M., Hatt H. (2005) A potential role of odorant receptor agonists and antagonists in the treatment of infertility and contraception. Current Opinion in Investigational Drugs 6(4): 364-368

• Neuhaus E.M., Gisselmann G., Zhang W., Dooley R., Störtkuhl K., Hatt H. (2005) Odorant receptor heterodimerization in the olfactory system of Drosophila melanogaster . Nature Neurosci. 8: 15-17

• Zhainazarov A.B., Spehr M., Wetzel C.H., Hatt H., Ache B.W. (2004) Modulation of the olfactory CNG channel by Ptdlns(3,4,5)P3. J. Membr. Biol. 201(1):51-7.

• Spicer B.A., Baker R.C., Hatt H., Laycock SM, Smith H. (2004) The effects of drugs on Sephadex-induced eosinophilia and lung hyper-responsiveness in the rat. Br. J. Pharmacol. 101: 821-828

• Spehr M., Schwane K., Riffell J.A., Barbour J., Zimmer R.K., Neuhaus E.M., Hatt H. (2004) Particulate adenylate cyclase plays a key role in human sperm olfactory receptor-mediated chemotaxis. J. Biol. Chem. 279(38): 40194-40203

• Spehr M, Schwane K, Heilmann S, Gisselmann G, Hummel T, Hatt H., (2004) Dual capacity of a human olfactory receptor. Curr Biol. 2004 14(19):R832-3

• Spehr J., Spehr M., Hatt H., Wetzel Ch.H. (2004) Subunit-specific P2X-receptor expression defines chemosensory properties of trigeminal neurons. Europ. J. Neurosi. 19: 2497-2510

• Spehr M., Hatt, H. (2004) hOR17-4 as a potential therapeutic target. Drug News Perspect 17: 165-171

• Hatt H. (2004) Doppelfunktion von Riechrezeptoren in Nase und Spermien. Bioforum 12: 2-4

• Hatt H. (2004) Physiologie oder Medizin. Naturwiss. Rundschau: 676-677

• Hatt H. (2004) Olfaction: "lower sense" achieves high significance. Dtsch. Med. Wochenschr. 129(46):2458-60.

• Hatt H. (2004) Molecular and cellular basis of human olfaction. Chem. & Biodiv. 1: 1857-1869

• Gisselmann G, Wetzel CH, Warnstedt M, Hatt H. (2004) Functional characterization of Ih-channel splice variants from Apis mellifera. FEBS Lett. 575(1-3):99-104.

• Gisselmann G, Plonka J, Pusch H, Hatt H. (2004) Unusual functional properties of homo- and heteromultimeric histamine-gated chloride channels of Drosophila melanogaster: spontaneous currents and dual gating by GABA and histamine. Neurosi. Lett. 372(1-2):151-6.

• Gisselmann G., Plonka J., Pusch H., Hatt H. (2004) Drosophila melanogaster GRD and LCCH3 subunits form heteromultimeric GABA-gated cation channels. Br. J. Pharmacol 142: 409-413

• Behrendt H.J., Germann T., Gillen C., Hatt H., Jostock R. (2004) Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol 141: 737-745

• Gisselmann G, Warnstedt M, Gamerschlag B, Bormann A, Marx T, Neuhaus EM, Stoertkuhl K, Wetzel CH, Hatt H. (2003) Characterization of recombinant and native Ih-channels from Apis mellifera. Insect Biochem Mol Biol. 33:1123-1134

• Zhang Y, Oliva R, Gisselmann G, Hatt H, Guckenheimer J, Harris-Warrick RM. (2003)  Overexpression of a hyperpolarization-activated cation current (Ih) channel gene modifies the firing activity of identified motor neurons in a small neural network. J Neurosci. 23:9059-9067

• Spehr M, Gisselmann G, Poplawski A, Riffell JA, Wetzel CH, Zimmer RK, Hatt H (2003) Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science 299: 2054-2058.

• Lang K, Hatt H, Niggemann B, Zaenker KS, Entschladen F (2003) A novel function for chemokines: downregulation of neutrophil migration. Scand J Immunol 57: 350-361.

• Spehr M, Hatt H, Wetzel CH (2002) Arachidonic acid plays a role in rat vomeronasal signal transduction. J Neurosci 22: 8429-8437.

• Gisselmann G, Galler A, Friedrich F, Hatt H, Bormann J (2002) Cloning and functional characterization of two glycine receptor alpha-subunits from the perch retina. Eur J Neurosci 16: 69-80.

• Mohrmann R, Kohr G, Hatt H, Sprengel R, Gottmann K (2002) Deletion of the C-terminal domain of the NR2B subunit alters channel properties and synaptic targeting of N-methyl-D-aspartate receptors in nascent neocortical synapses. J Neurosci Res 68: 265-275.

• Kroner S, Gottmann K, Hatt H, Gunturkun O (2002) Electrophysiological and morphological properties of cell types in the chick neostriatum caudolaterale. Neuroscience 110: 459-473.

• Spehr M, Wetzel CH, Hatt H, Ache BW (2002) 3-phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neurons. Neuron 33: 731-739.

• Gisselmann G, Pusch H, Hovemann BT, Hatt H (2002) Two cDNAs coding for histamine-gated ion channels in D. melanogaster. Nat Neurosci 5: 11-12.

• Wetzel CH, Spehr M, Hatt H (2001) Phosphorylation of voltage-gated ion channels in rat olfactory receptor neurons. Eur J Neurosci 14: 1056-1064.

• Hatt H, Lang K, Gisselmann G (2001) Functional expression and characterization of odorant receptors using the Semliki Forest virus system. Biol Chem 382: 1207-1214.

• Wetzel CH, Behrendt HJ, Gisselmann G, Störtkuhl KF, Hovemann B, Hatt H (2001) Functional expression and characterization of a Drosophila odorant receptor in a heterologous cell system. Proc Natl Acad Sci U S A 98: 9377-9380.

• Lobitz N, Gisselmann G, Hatt H, Wetzel CH (2001) A single amino-acid in the TM1 domain is an important determinant of the desensitization kinetics of recombinant human and guinea pig alpha-homomeric 5-hydroxytryptamine type 3 receptors. Mol Pharmacol 59: 844-851.

• Rumpel S, Hoffmann H, Hatt H, Gottmann K, Mittmann T, Eysel UT (2000) Lesion-induced changes in NMDA receptor subunit mRNA expression in rat visual cortex. Neuroreport 11: 4021-4025.

• Hoffmann H, Gremme T, Hatt H, Gottmann K (2000) Synaptic activity-dependent developmental regulation of NMDA receptor subunit expression in cultured neocortical neurons. J Neurochem 75: 1590-1599.

• Mohrmann R, Hatt H, Gottmann K (2000) Developmental regulation of subunit composition of extrasynaptic NMDA receptors in neocortical neurones. Neuroreport 11: 1203-1208.

• Lankiewicz S, Huser MB, Heumann R, Hatt H, Gisselmann G (2000) Phosphorylation of the 5-hydroxytryptamine3 (5-HT3) receptor expressed in HEK293 cells. Receptors Channels 7: 9-15.

• Mohrmann R, Werner M, Hatt H, Gottmann K (1999) Target-specific factors regulate the formation of glutamatergic transmitter release sites in cultured neocortical neurons. J Neurosci 19: 10004-10013.

• Wetzel CH, Oles M, Wellerdieck C, Kuczkowiak M, Gisselmann G, Hatt H (1999) Specificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus Laevis oocytes. J Neurosci 19: 7426-7433.

• Hatt H, Gisselmann G, Wetzel CH (1999) Cloning, functional expression and characterization of a human olfactory receptor. Cell Mol Biol (Noisy -le-grand) 45: 285-291.

• Hatt H (1999) Modification of glutamate receptor channels: molecular mechanisms and functional consequences. Naturwissenschaften 86: 177-186.

• Marx T, Gisselmann G, Störtkuhl KF, Hovemann BT, Hatt H (1999) Molecular cloning of a putative voltage- and cyclic nucleotide-gated ion channel present in the antennae and eyes of Drosophila melanogaster. Invert Neurosci 4: 55-63.Okada T, Schultz K, Geurtz W, Hatt H, Weiler R (1999) AMPA-preferring receptors with high Ca2+ permeability mediate dendritic plasticity of retinal horizontal cells. Eur J Neurosci 11: 1085-1095.

• Brunig I, Sommer M, Hatt H, Bormann J (1999) Dopamine receptor subtypes modulate olfactory bulb gamma-aminobutyric acid type A receptors. Proc Natl Acad Sci U S A 96: 2456-2460.

• Rumpel S, Hatt H, Gottmann K (1998) Silent synapses in the developing rat visual cortex: evidence for postsynaptic expression of synaptic plasticity. J Neurosci 18: 8863-8874.

• Ziegler C, Gopel W, Hammerle H, Hatt H, Jung G, Laxhuber L, Schmidt HL, Schutz S, Vogtle F, Zell A (1998) Bioelectronic noses: a status report. Part II. Biosens Bioelectron 13: 539-571.

• Werner M, Hatt H, Gottmann K (1998) Afferent innervation influences HVA Ca2+ current expression in cultured neocortical neurones. Neuroreport 9: 1255-1260.

• Lindlbauer R, Mohrmann R, Hatt H, Gottmann K (1998) Regulation of kinetic and pharmacological properties of synaptic NMDA receptors depends on presynaptic exocytosis in rat hippocampal neurones. J Physiol 508 ( Pt 2): 495-502.

• Lankiewicz S, Lobitz N, Wetzel CH, Rupprecht R, Gisselmann G, Hatt H (1998) Molecular cloning, functional expression, and pharmacological characterization of 5-hydroxytryptamine3 receptor cDNA and its splice variants from guinea pig. Mol Pharmacol 53: 202-212.

• Werner M, Hatt H, Gottmann K (1998) Synapse formation and morphological differentiation of neuron types in embryonic rat dentate gyrus explants in vitro. Brain Res Dev Brain Res 105: 9-23.

• Werner M, Hatt H, Gottmann K (1998) Synapse formation and morphological differentiation of neuron types in embryonic rat dentate gyrus explants in vitro. Brain Res Dev Brain Res 105: 9-23.

• Temkin R, Lowe D, Jensen P, Hatt H, Smith DO (1997) Expression of glutamate receptor subunits in alpha-motoneurons. Brain Res Mol Brain Res 52: 38-45.

• Hoffmann H, Hatt H, Gottmann K (1997) Presynaptic exocytosis regulates NR2A mRNA expression in cultured neocortical neurones. Neuroreport 8: 3731-3735.

• Wellerdieck C, Oles M, Pott L, Korsching S, Gisselmann G, Hatt H (1997) Functional expression of odorant receptors of the zebrafish Danio rerio and of the nematode C. elegans in HEK293 cells. Chem Senses 22: 467-476.

• Lankiewicz S, Gisselmann G, Hatt H (1997) Enhanced RACE method using specific enrichment by biotinylated oligonucleotides bound to streptavidin coated magnetic particles. Nucleic Acids Res 25: 2037-2038.

• Gottmann K, Mehrle A, Gisselmann G, Hatt H (1997) Presynaptic control of subunit composition of NMDA receptors mediating synaptic plasticity. J Neurosci 17: 2766-2774.

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